The tie will take place at 14:30 GMT on Sunday, 9th March 2025. It will also be broadcast live on FA channels.
It was Chelsea that knocked the Eagles out in last years' edition of the FA Cup, with Mayra Ramirez scoring late at Kingsmeadow to give the Blues a 1-0 win.
Sonia Bompastor's side were also the first-ever team that Palace played at home in the Barclays Women's Super League.
Should the match end in a draw, extra-time and penalties will determine who will advance.
Stay tuned to cpfc.co.uk, the official App and across our social media channels for confirmed ticketing details.