Paddy McCarthy has named a strong lineup for the clash, including players such as TQ Addy, Rob Street and Brandon Aveiro who have previously stepped up to Under-23 level.
There have been four changes made to the side who played against Bristol City two weeks ago.
Palace: Russell, Keutcha, Chamberlin-Gayle, Boateng, Onoabhagbe, Siddik, Aveiro, Boateng, Street, Donkin, Addy.
Subs: Luthra, Russell, Omilabu, Ajayi, Gurung.
Bolton: James, Whalley, White, Graham, Senior, Broughton, King-Harmes, Connell (C), Brown, Darcy, Argent-Barnes.
Subs: Preston, Alexander, Brown-Sterling, Holmes, Lockett.